Estrogen is a hormone that, among other things, helps determine where the body stores fat and supports the maintenance of muscle mass. While estrogen levels are adequate, fat tends to be stored around the hips and thighs. As levels decline through perimenopause and menopause, that balance shifts and fat moves more toward the abdomen and around the internal organs – visceral fat. A review published in the Journal of Clinical Medicine, along with other research focused specifically on the menopause transition, links this shift partly to a relative rise in the testosterone-to-estradiol ratio after menopause.
Alongside the shift in fat, muscle mass also declines. According to expert reviews of menopause and muscle, summarized among others by The Menopause Society, falling estradiol combined with rising FSH is associated with muscle catabolism – the breakdown of muscle protein. Part of the mechanism likely runs through a mild increase in inflammatory processes in the body, which promote protein breakdown while dampening the anabolic, muscle-building pathways.
It's worth not treating these mechanisms as a fixed script that plays out identically for every woman. The speed and extent of the changes vary considerably between individuals – genetics, activity level, diet, sleep and overall health all play a role. What the research explains is why changes tend to happen faster and more often during this life stage, not exactly what will happen, or how strongly, in your specific case.